N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide
• CAS No.: 31523-10-1
• Molecular Formula: C₁₅H₁₄N₂O₃S
• Molecular Weight: 302.354
• Mol file: 31523-10-1.mol

Synonyms:N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide

There total 2 articles about N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-1,3-dihydro-2H-indol-2-one (20876-36-2) + p-toluenesulfonyl chloride (98-59-9) → N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide (31523-10-1)

Guidance literature:

In water; at 20 ℃;

Reference yield:

5-nitrooxindole (20870-79-5) → N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide (31523-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / ethanol / 20 °C

2: water / 20 °C

With palladium on activated charcoal; hydrogen; In ethanol; water;

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) + N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methylbenzenesulfonamide (31523-10-1) → 4-methyl-N-(2-oxo-3-(4-phenylcyclohexylidene)indolin-5-yl)benzenesulfonamide + (aR)-4-methyl-N-(2-oxo-3-(4-phenylcyclohexylidene)indolin-5-yl)benzenesulfonamide

Guidance literature:

With (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanamine; 3,5-dinitrobenzoic acid; In toluene; at 40 ℃; for 24h; Overall yield = 46 %; Overall yield = 42.6 mg; enantioselective reaction; Molecular sieve; Darkness;

DOI:10.1021/acs.orglett.9b00505

upstream raw materials:

5-nitrooxindole

5-amino-1,3-dihydro-2H-indol-2-one

p-toluenesulfonyl chloride