tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Base Information

Chemical Name:tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate
CAS No.:478163-10-9
Molecular Formula:C₂₄H₃₀FNO₄
Molecular Weight:415.505
Hs Code.:

Synonyms:tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Suppliers and Price of tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

There total 5 articles about tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 478163-09-6
4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)acetophenone

: 5292-43-3
bromoacetic acid tert-butyl ester

: 478163-10-9
tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Guidance literature:: 4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)acetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -65 ℃; for 0.416667h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -65 - 20 ℃; for 2.16667h;

Reference yield:

: 446-51-5
2-fluorobenzyl alcohol

: 478163-10-9
tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: 7 h / 120 °C / Inert atmosphere

3.1: thionyl chloride / toluene / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.42 h / -65 °C / Inert atmosphere

5.2: 2.17 h / -65 - 20 °C

With thionyl chloride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 478163-07-4
2-fluorobenzyl methanesulfonate

: 478163-10-9
tert-butyl 4-[4-(2-(N-(2-fluorobenzyl)-N-methylamino)ethoxy)phenyl]-4-oxobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 7 h / 120 °C / Inert atmosphere

2.1: thionyl chloride / toluene / 16 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.42 h / -65 °C / Inert atmosphere

4.2: 2.17 h / -65 - 20 °C

With thionyl chloride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;