2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

Base Information

Chemical Name:2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione
CAS No.:1310549-03-1
Molecular Formula:C₂₁H₂₂ClFN₂O₄S
Molecular Weight:452.934
Hs Code.:

Synonyms:2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

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Chemical Property of 2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

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Technology Process of 2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

There total 3 articles about 2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1310548-96-9
1-(3-chloro-2-fluorobenzyl)-1H-pyrrole-2,5-dione

: 221444-85-5
1-ethylsulfinylacetylazepan-2-one

: 1310549-03-1
2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

Guidance literature:: With acetic anhydride; toluene-4-sulfonic acid; In toluene; for 1h; Reflux;
DOI:10.1016/j.bmcl.2011.03.047

Reference yield:

: 221444-88-8
1-ethylsulfenylacetylazepan-2-one

: 1310549-03-1
2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate

2: acetic anhydride; toluene-4-sulfonic acid / toluene / 1 h / Reflux

With sodium periodate; acetic anhydride; toluene-4-sulfonic acid; In toluene; 2: Pummerer cyclization deprotonation cycloaddition;
DOI:10.1016/j.bmcl.2011.03.047

Reference yield:

: 72235-55-3
(3-chloro-2-fluorophenyl)methanamine

: 1310549-03-1
2-(3-chloro-2-fluorobenzyl)-4-(ethylthio)hexahydro-4,11a-epoxypyrrolo[3',4':3,4]pyrido[1,2-a]azepine-1,3,5(2H,7H,11bH)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 20 °C / Reflux

2: acetic anhydride; toluene-4-sulfonic acid / toluene / 1 h / Reflux

With acetic anhydride; toluene-4-sulfonic acid; In acetic acid; toluene; 2: Pummerer cyclization deprotonation cycloaddition;
DOI:10.1016/j.bmcl.2011.03.047