5-(TRIFLUOROMETHYL)-URIDINE

Base Information

• Chemical Name: 5-(TRIFLUOROMETHYL)-URIDINE
• CAS No.: 21618-67-7
• Molecular Formula: C10H11 F3 N2 O6
• Molecular Weight: 312.202
• Mol file: 21618-67-7.mol

Synonyms:5-(Trifluoromethyl)uridine

Chemical Property of 5-(TRIFLUOROMETHYL)-URIDINE

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 7.75±0.10(Predicted)
• Flash Point: °C
• PSA: 124.78000
• Density: 1.765g/cm³
• LogP: -1.83310

Purity/Quality:

98%Min ^*data from raw suppliers

5-(Trifluoromethyl)uridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Trifluoromethyl)uridine is an analog of Uridine (U829910) and used as a reagent in the synthesis of β-D-arabinofuranosyl and deoxyfluoro-β-D-ribofuranosyl pyrimidine nucleoside analogs which exhibit antituberculosis activity against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium in vitro.

Technology Process of 5-(TRIFLUOROMETHYL)-URIDINE

There total 12 articles about 5-(TRIFLUOROMETHYL)-URIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate (65499-41-4) → 5-(trifluoromethyl)uridine (21618-67-7)

Guidance literature:

With methanol; acetyl chloride; at 0 ℃; for 10h;

Reference yield: 68.0%

5-(trifluoromethyl)-2',5'-di-O-trityluridine (76513-97-8) → 5-(trifluoromethyl)uridine (21618-67-7)

Guidance literature:

With acetic acid; for 0.166667h; Heating;

DOI:10.1039/P19800002755

Reference yield: 42.0%

Langlois reagent (2926-29-6) + uridine (58-96-8) → 5-(trifluoromethyl)uridine (21618-67-7)

Guidance literature:

With mesoporous graphitic carbon nitride; In dimethyl sulfoxide; at 25 ℃; Irradiation;

DOI:10.1126/science.aaw3254

upstream raw materials:

5-(trifluoromethyl)-2',5'-di-O-trityluridine

2',5'-di-O-trityl-5-iodouridine

iodotrifluoromethane

uridine

Downstream raw materials:

2'-deoxy-5-trifluoromethyluridine

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