{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

Base Information

Chemical Name:{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile
CAS No.:1462470-53-6
Molecular Formula:C₂₇H₃₇N₃O₄
Molecular Weight:467.608
Hs Code.:

Synonyms:{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

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Chemical Property of {2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

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Technology Process of {2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

There total 12 articles about {2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 866783-13-3
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

: 1462470-52-5
(2-{2-[(3-chloropropyl)amino]ethyl}-4,5-dimethoxyphenyl)acetonitrile

: 1462470-53-6
{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

Guidance literature:: With triethylamine; In acetonitrile; for 6h; Reflux;

Reference yield:

: 1031767-71-1
(S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2,0]octa-1⁽⁶⁾,2,4-trien-7-yl)methyl)-N-methylpropan-1-amine

: 121851-67-0
[2-(2-aminoethyl)-4,5-dimethoxyphenyl]acetonitrile

: 1462470-53-6
{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

Guidance literature:: With triethylamine; potassium iodide; In acetonitrile; at 20 - 60 ℃; for 24h;

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1462470-53-6
{2-[2-({3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)-amino]propyl}amino)ethyl]-4,5-dimethoxyphenyl}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate / 1 h / 20 °C

2: hydrogenchloride / water; dichloromethane / 3 h / 0 - 40 °C

3: dimethyl sulfoxide / 1.5 h / 20 °C

4: potassium carbonate / ethanol; water / 1.5 h / 50 °C

5: potassium iodide; triethylamine / acetonitrile / 24 h / 20 - 60 °C

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; In ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;