(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

Base Information

Chemical Name:(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one
CAS No.:1354005-17-6
Molecular Formula:C₁₆H₁₀BrF₃O₂
Molecular Weight:371.153
Hs Code.:

Synonyms:(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

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Chemical Property of (S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

Chemical Property:

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Technology Process of (S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

There total 2 articles about (S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₁F₃O₂

: 1354005-17-6
(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

: (R)-3-((S)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

: (3R,4S)-4-bromo-3-[4-(trifluoromethyl)phenyl]-3,4-dihydroisochromen-1-one

Guidance literature:: With C₃₂H₂₉N₃O₃S; dibromoisocyanuric acid; In dichloromethane; at 0 ℃; for 24h; Reagent/catalyst; stereoselective reaction;
DOI:10.1055/s-0037-1610716

Reference yield:

: (E)-2-(4-(trifluoromethyl)styryl)benzoic acid

: 1354005-17-6
(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

: (R)-3-((S)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

: (3R,4S)-4-bromo-3-[4-(trifluoromethyl)phenyl]-3,4-dihydroisochromen-1-one

: 1354004-96-8
(3S,4R)-4-bromo-3-[4-(trifluoromethyl)phenyl]-3,4-dihydroisochromen-1-one

Guidance literature:: With N-Bromosuccinimide; C₂₉H₃₃N₃O₄S; In dichloromethane; at -45 ℃; for 120h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Darkness;
DOI:10.1021/jo202221c

Reference yield: 92.0%

: 1354005-17-6
(S)-3-((R)-bromo[4-(trifluoromethyl)phenyl]methyl)isobenzofuran-1(3H)-one

: 1354005-22-3
(R)-3-[4-(trifluoromethyl)benzyl]isobenzofuran-1(3H)-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); triphenylstannane; In toluene; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jo202221c