1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

Base Information

Chemical Name:1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea
CAS No.:1251863-16-7
Molecular Formula:C₂₂H₂₁F₃N₆O₄
Molecular Weight:490.442
Hs Code.:

Synonyms:1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

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Chemical Property of 1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

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Technology Process of 1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

There total 8 articles about 1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86718-01-6
methyl 7-imidazo<1,2-a>pyridinecarboxylate

: 1251863-16-7
1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / methanol / Reflux

2.1: sulfuric acid / 80 °C

3.1: triphenylphosphine; caesium carbonate / palladium diacetate / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

4.1: tetrahydrofuran / 20 - 60 °C

4.2: 20 °C

5.1: 1,4-dioxane; water / 20 - 100 °C / Molecular sieve; Microwave biotage device

With sulfuric acid; caesium carbonate; hydrazine hydrate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;

Reference yield:

: 75-90-1
2,2,2-Trifluoroacetaldehyde

: 1251863-15-6
{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}urea

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: 1251863-16-7
1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

Guidance literature:: In 1,4-dioxane; water; at 20 - 100 ℃; Molecular sieve; Microwave biotage device;

Reference yield:

: 116632-23-6
3-bromo-5-nitro-phenol

: 1251863-16-7
1-{3-isopropoxy-5-[7-(5-methyl[1,3,4]oxadiazol-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoro-1-hydroxyethyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: titanium(III) chloride / tetrahydrofuran / 48 h / 20 °C

3.1: triphenylphosphine; caesium carbonate / palladium diacetate / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

4.1: tetrahydrofuran / 20 - 60 °C

4.2: 20 °C

5.1: 1,4-dioxane; water / 20 - 100 °C / Molecular sieve; Microwave biotage device

With titanium(III) chloride; potassium carbonate; caesium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;