1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-

Base Information

Chemical Name:1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-
CAS No.:90513-98-7
Molecular Formula:C₁₈H₂₀F₃N₃O₃
Molecular Weight:383.37
Hs Code.:
DSSTox Substance ID:DTXSID90920344

Synonyms:BRN 0945029;1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-;90513-98-7;DTXSID90920344;N,N-Diethyl-1,3-dioxo-2-[3-(trifluoromethyl)phenyl]hexahydro-1H-pyrrolo[1,2-c]imidazole-5-carboxamide

Suppliers and Price of 1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:383.14567599
Heavy Atom Count:27
Complexity:621

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)C1CCC2N1C(=O)N(C2=O)C3=CC=CC(=C3)C(F)(F)F

Technology Process of 1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)-

There total 5 articles about 1H-Pyrrolo(1,2-c)imidazole-5-carboxamide, hexahydro-N,N-diethyl-1,3-dioxo-2-(3-(trifluoromethyl)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41994-50-7
diethyl meso-2,5-pyrrolidinedicarboxylate

: 90513-98-7
1,3-dioxo-2-(3-trifluoromethyl-phenyl)-hexahydro-pyrrolo[1,2-c]imidazole-5-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / diethyl ether / 1 h / Heating; room temp., 15 min.

2: 75 percent / 18percent hydrochloric acid / H₂O / 1.5 h

3: 1.) ethyl chloroformate, triethylamine / 1.) benzene, ether, 0 deg C, 15 min; 2.) benzene, ether, room temp. 20 min

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In diethyl ether; water;

Reference yield:

: 90513-65-8
1-(3-Trifluoromethyl-phenylcarbamoyl)-pyrrolidine-2,5-dicarboxylic acid diethyl ester

: 90513-98-7
1,3-dioxo-2-(3-trifluoromethyl-phenyl)-hexahydro-pyrrolo[1,2-c]imidazole-5-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 18percent hydrochloric acid / H₂O / 1.5 h

2: 1.) ethyl chloroformate, triethylamine / 1.) benzene, ether, 0 deg C, 15 min; 2.) benzene, ether, room temp. 20 min

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In water;

Reference yield:

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 90513-98-7
1,3-dioxo-2-(3-trifluoromethyl-phenyl)-hexahydro-pyrrolo[1,2-c]imidazole-5-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / diethyl ether / 1 h / Heating; room temp., 15 min.

2: 75 percent / 18percent hydrochloric acid / H₂O / 1.5 h

3: 1.) ethyl chloroformate, triethylamine / 1.) benzene, ether, 0 deg C, 15 min; 2.) benzene, ether, room temp. 20 min

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In diethyl ether; water;