methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

Base Information

Chemical Name:methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate
CAS No.:638214-46-7
Molecular Formula:C₂₆H₂₆F₃NO₃
Molecular Weight:457.493
Hs Code.:

Synonyms:methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

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Chemical Property of methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

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Technology Process of methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

There total 10 articles about methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638214-09-2
1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 638214-46-7
methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

Guidance literature:: 1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol; Methyl 4-hydroxyphenylacetate; With diazene-1,2-diylbis(morpholinomethanone); In tetrahydrofuran; at 0 ℃; for 0.05h;

With tributylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 64h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 638214-46-7
methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 100 °C

2.1: diazene-1,2-diylbis(morpholinomethanone) / tetrahydrofuran / 0.05 h / 0 °C

2.2: 64 h / 0 - 20 °C

With diazene-1,2-diylbis(morpholinomethanone); sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling / 2.1: Mitsunobu reaction;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638214-46-7
methyl {4-[(1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]phenyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C

1.2: 0.27 h / -78 °C

2.1: manganese(IV) oxide / chloroform / 7.5 h

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 17.5 h / Heating / reflux

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 2.58 - 2.67 h / 0 °C

5.1: diazene-1,2-diylbis(morpholinomethanone) / tetrahydrofuran / 0.05 h / 0 °C

5.2: 64 h / 0 - 20 °C

With diazene-1,2-diylbis(morpholinomethanone); manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexanes; 1,2-dimethoxyethane; chloroform; water; 3.1: Suzuki Coupling / 5.1: Mitsunobu reaction;