5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

Base Information

Chemical Name:5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one
CAS No.:1325205-34-2
Molecular Formula:C₁₅H₁₄ClN₃O₃
Molecular Weight:319.747
Hs Code.:

Synonyms:5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

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Chemical Property of 5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

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Technology Process of 5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

There total 3 articles about 5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3296-06-8
1-azido-3-chlorobenzene

: 1325205-32-0
5-[(trimethylsilyl)ethynyl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 1325205-34-2
5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

Guidance literature:: With copper(l) iodide; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 0.0833333h; Inert atmosphere; Sonication;
DOI:10.1016/j.tetlet.2011.04.072

Reference yield:

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 1325205-34-2
5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide; acetic acid / Darkness

2: copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 3 h / 80 °C / Inert atmosphere

3: copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 25 °C / Inert atmosphere; Sonication

With N-iodo-succinimide; copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.04.072

Reference yield:

: 142779-83-7
5-iodo-2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 1325205-34-2
5-[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-2,2,6-trimethyl-4H-1,3-dioxin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 3 h / 80 °C / Inert atmosphere

2: copper(l) iodide; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 25 °C / Inert atmosphere; Sonication

With copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; acetonitrile; 1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.04.072