(2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
CAS No.:138037-93-1
Molecular Formula:C₁₄H₁₆BrNO₄
Molecular Weight:342.189
Hs Code.:

Synonyms:(2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

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Technology Process of (2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

There total 6 articles about (2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 139575-14-7,120672-87-9
N-(4-bromobenzylidene)glycine methyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 138037-93-1
(2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: With C₃₆H₃₆FeN₃PS; silver(I) acetate; triethylamine; In dichloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.07.085

Reference yield:

: 139575-14-7,120672-87-9
N-(4-bromobenzylidene)glycine methyl ester

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 138037-93-1
(2R,4R,5S)-dimethyl 5-(4-bromophenyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: With C₄₄H₄₉N₄O₂P; silver(l) oxide; In toluene; at -5 ℃; Inert atmosphere;
DOI:10.1055/s-0040-1706053

Reference yield:

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 139575-14-7
methyl 2-[(E)-[(4-bromophenyl)methylidene]amino]acetate

: 138037-93-1
(2R,4R,5S)-dimethyl 5-(4-bromophenyl)pyrrolidine-2,4-dicarboxylate

: 138037-93-1
(2S,4S,5R)-5-(4-Bromo-phenyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: With (S)-C₁₇H₃₀N₂O₂; zinc trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; at -20 ℃; Title compound not separated from byproducts;
DOI:10.1002/1521-3773(20021115)41:22<4236::AID-ANIE4236>3.0.CO;2-W