(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

Base Information

Chemical Name:(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline
CAS No.:1434175-88-8
Molecular Formula:C₃₈H₅₇N₃O₄Sn
Molecular Weight:738.598
Hs Code.:

Synonyms:(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

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Chemical Property of (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

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Technology Process of (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

There total 6 articles about (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.3%

: 1434175-83-3
(E)-4-[2-(6-bromo-1-tert-butoxycarbonylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

: 813-19-4
bis(tri-n-butyltin)

: 1434175-88-8
(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; triethylamine; for 5h; Reflux;
DOI:10.1016/j.bmc.2013.02.054

Reference yield:

: 1434175-67-3
(E)-6-bromo-2-(4-nitrostyryl)-1H-benzimidazole

: 1434175-88-8
(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; iron / ethanol; water / 24 h / Reflux

2.1: sodium methylate / methanol / 1 h / Reflux

2.2: 2 h / Reflux

3.1: guanidine hydrochloride / ethanol / 2 h / 40 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 5 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; guanidine hydrochloride; sodium methylate; iron; In 1,4-dioxane; methanol; ethanol; water; triethylamine;
DOI:10.1016/j.bmc.2013.02.054

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1434175-88-8
(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonyl-N-methylaniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium metabisulfite / N,N-dimethyl-formamide / 2 h / 105 °C

2.1: hydrogenchloride; iron / ethanol; water / 24 h / Reflux

3.1: sodium methylate / methanol / 1 h / Reflux

3.2: 2 h / Reflux

4.1: guanidine hydrochloride / ethanol / 2 h / 40 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 5 h / Reflux

With hydrogenchloride; sodium metabisulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; guanidine hydrochloride; sodium methylate; iron; In 1,4-dioxane; methanol; ethanol; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.02.054