2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

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Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
CAS No.:1287779-23-0
Molecular Formula:C₁₉H₁₆N₄O₃
Molecular Weight:348.361
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

There total 6 articles about 2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287779-17-2
2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: 1287779-23-0
2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

: 1287779-20-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 60 ℃; pH=7; Inert atmosphere; Sealed tube;

Reference yield:

: 1287779-68-3
2-bromo-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: 1287779-23-0
2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

: 1287779-20-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 20 - 90 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydroxide / water; dimethyl sulfoxide / 60 °C / pH 7 / Inert atmosphere; Sealed tube

With hydroxylamine hydrochloride; sodium hydrogencarbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield:

: 860362-11-4
1-acetyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: 1287779-23-0
2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

: 1287779-20-7
2-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboximidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / ethanol / 1 h

2.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 110 °C / Inert atmosphere; Sealed tube

3.1: n-butyllithium / -78 - -40 °C

3.2: 2.5 h / -78 °C

4.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 20 - 90 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; sodium hydroxide / water; dimethyl sulfoxide / 60 °C / pH 7 / Inert atmosphere; Sealed tube

With potassium phosphate; copper(l) iodide; n-butyllithium; hydroxylamine hydrochloride; water; boron tribromide; sodium hydrogencarbonate; sodium hydroxide; N,N`-dimethylethylenediamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;