(S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol

Base Information

• Chemical Name: (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol
• CAS No.: 1221817-53-3
• Molecular Formula: C₅₅H₄₅F₁₂N₃O
• Molecular Weight: 991.963
• Mol file: 1221817-53-3.mol

Synonyms:(S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol

Chemical Property of (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol

There total 1 articles about (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol (1221817-48-6) → (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol (1221817-53-3)

Guidance literature:

With thiophenol; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja101216x

Reference yield:

thiophosgene (463-71-8) + (S)-2-amino-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]aminopropane-1-ol (1221817-53-3) → C56H43F12N3OS

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 0 - 5 ℃; for 1h;

DOI:10.1021/ja101216x

upstream raw materials:

(S)-1,1-bis[3,5-bis(trifluoromethyl)phenyl]-3-[6,7-dihydro-5H-6-(triphenylmethylaminomethyl)dibenzo[a,c]cycloheptene-6-ylmethyl]amino-2-(2-nitrobenzenesulfonyl)aminopropane-1-ol