2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

Base Information

Chemical Name:2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester
CAS No.:848004-54-6
Molecular Formula:C₃₄H₃₉N₃O₁₂
Molecular Weight:681.697
Hs Code.:

2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1<i>H</i>,5<i>H</i>-benzo[<i>e</i>]pyrrolo[1,2-<i>a</i>][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

Synonyms:2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

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Chemical Property of 2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

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Technology Process of 2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

There total 5 articles about 2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 848004-54-6
2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

Guidance literature:

Reference yield: 62.0%

: 848004-52-4
(S)-2-{4-[2-((S)-2-Hydroxymethyl-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenylcarbamoyloxymethyl]-phenoxycarbonylamino}-pentanedioic acid diallyl ester

: 848004-54-6
2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2005.10.017

Reference yield:

: 848004-19-3
(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

: 848004-54-6
2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid diallyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TEA / toluene / 2 h / 20 °C

2: TEA / CH₂Cl₂ / 18 h / 20 °C

3: 91 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C

4: 62 percent / pyridinium dichromate; 4 Angstroem sieves / CH₂Cl₂ / 2 h / 20 °C

With dipyridinium dichromate; 4 A molecular sieve; TEA; acetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.10.017