(Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate

Base Information

• Chemical Name: (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate
• CAS No.: 1255517-01-1
• Molecular Formula: C₁₁H₁₀BrNO₄
• Molecular Weight: 300.109
• Mol file: 1255517-01-1.mol

Synonyms:(Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate

Chemical Property of (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate

There total 4 articles about (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

nitroacetic acid ethyl ester (626-35-7) + 4-bromo-benzaldehyde (1122-91-4) → (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate (1255517-01-1)

Guidance literature:

With acetic acid; 3-amino propanoic acid; In benzene; for 5h; Dean-Stark; Reflux;

DOI:10.1134/S1070363216060086

Reference yield:

nitroacetic acid ethyl ester (626-35-7) + N-(4-bromobenzylidene)aniline (5877-51-0) → (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate (1255517-01-1)

Guidance literature:

With acetic anhydride; at 50 ℃; for 17h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.06.046

Reference yield:

nitroacetic acid ethyl ester (626-35-7) + 4-bromo-benzaldehyde (1122-91-4) → (Z)-ethyl 3-(4-bromophenyl)-2-nitropropenoate (1255517-01-1) + ethyl 3-(4-bromophenyl)-2-nitroacrylate

Guidance literature:

nitroacetic acid ethyl ester; 4-bromo-benzaldehyde; With titanium tetrachloride; In tetrahydrofuran; dichloromethane; at -10 ℃; for 0.666667h; Inert atmosphere;

With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; at -10 - 20 ℃; for 18h; Overall yield = 73 percent; Overall yield = 354.4 mg; Inert atmosphere;

DOI:10.1039/d1ob00270h

upstream raw materials:

nitroacetic acid ethyl ester

N-(4-bromobenzylidene)aniline

4-bromo-benzaldehyde

Downstream raw materials:

(4S,5R)-4-(4-bromophenyl)-3-(ethoxycarbonyl)-5-formyl-5-propyl-4,5-dihydroisoxazole 2-oxide