(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

Base Information

Chemical Name:(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate
CAS No.:1248570-73-1
Molecular Formula:C₂₉H₃₄N₂O₁₄
Molecular Weight:634.594
Hs Code.:

Synonyms:(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

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Chemical Property of (2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

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Technology Process of (2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

There total 5 articles about (2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 97609-58-0
chloromethyl 2-(acetyloxy)benzoate

: 1248570-72-0
3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(4-nitrooxybutoxy)benzoic acid

: 1248570-73-1
(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1002/cmdc.201300105

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1248570-73-1
(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / acetonitrile / 4 h / 70 °C

2.1: silver nitrate / acetonitrile / 14 h / 70 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

4.1: potassium permanganate / acetone / 1 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With dmap; potassium permanganate; potassium hydrogencarbonate; caesium carbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/cmdc.201300105

Reference yield:

: 1248570-61-7
4-(3-bromopropoxy)-3-hydroxybenzaldehyde

: 1248570-73-1
(2-acetyloxybenzoyl)oxymethyl 3-[3-(tert-butoxycarbonylamino)propanoyloxy]-4-(3-nitrooxybutoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: silver nitrate / acetonitrile / 14 h / 70 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: potassium permanganate / acetone / 1 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With dmap; potassium permanganate; caesium carbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/cmdc.201300105