4-Oxopyrrolidine-2-carboxylic acid;hydrobromide

Base Information

• Chemical Name: 4-Oxopyrrolidine-2-carboxylic acid;hydrobromide
• CAS No.: 75776-67-9
• Molecular Formula: C5H7NO3^.HBr
• Molecular Weight: 210.027
• Hs Code.: 2933990090
• NSC Number: 49884
• Mol file: 75776-67-9.mol

Synonyms:NSC49884;NSC-49884;AKOS032948022;FT-0682204

Chemical Property of 4-Oxopyrrolidine-2-carboxylic acid;hydrobromide

Chemical Property:

• Melting Point: 154-156 °C
• Boiling Point: 341.8oC at 760mmHg
• Flash Point: 160.5oC
• PSA: 66.40000
• Density: 1.38g/cm3
• LogP: 0.28890
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 208.96876
• Heavy Atom Count: 10
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

4-Oxo-L-proline hydrobromide 85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NCC1=O)C(=O)O.Br
• Uses: It is used as an active pharmaceutical intermediate. 4-Oxo-L-proline, a proline derivative, can be used as a site-specific infrared probe, since its C=O stretching vibration is sensitive to the surrounding environment.

Technology Process of 4-Oxopyrrolidine-2-carboxylic acid;hydrobromide

There total 1 articles about 4-Oxopyrrolidine-2-carboxylic acid;hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-oxo-L-proline ; hydrobromide (75776-67-9)

Guidance literature:

Reference yield:

3-(acetylthio)propanoyl chloride (41345-72-6) + 4-oxo-L-proline ; hydrobromide (75776-67-9) + N-cyclohexyl-cyclohexanamine (101-83-7) → 1-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline (75776-68-0)

Guidance literature:

With sodium carbonate; In chloroform; water; ethyl acetate;

Downstream raw materials:

1-[3-(acetylthio)-1-oxopropyl]-4-oxo-L-proline