(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

Base Information

Chemical Name:(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine
CAS No.:331731-30-7
Molecular Formula:C₁₄H₁₄Cl₃FN₂O₆
Molecular Weight:431.632
Hs Code.:

Synonyms:(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

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Technology Process of (R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

There total 4 articles about (R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 331731-29-4
(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine methyl ester

: 331731-30-7
(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

Guidance literature:: With lithium hydroxide; In water; tert-butyl alcohol; at 0 ℃; for 0.5h;
DOI:10.1021/ja003835i

Reference yield:

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 331731-30-7
(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / n-BuLi; CuCN

2: 87 percent / TFA

3: 82 percent / NaHCO₃ / CH₂Cl₂ / 3 h / 25 °C

4: 95 percent / LiOH*H₂O / H₂O; 2-methyl-propan-2-ol / 0.5 h / 0 °C

With lithium hydroxide; n-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; water; tert-butyl alcohol; 1: Schollkopf alkylation;
DOI:10.1021/ja003835i

Reference yield:

: 169825-21-2
D-(4-fluoro-3-nitrophenyl)glycine methyl ester

: 331731-30-7
(R)-N-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-4-fluoro-3-nitrophenyl-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaHCO₃ / CH₂Cl₂ / 3 h / 25 °C

2: 95 percent / LiOH*H₂O / H₂O; 2-methyl-propan-2-ol / 0.5 h / 0 °C

With lithium hydroxide; sodium hydrogencarbonate; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ja003835i