(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

Base Information

Chemical Name:(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine
CAS No.:656241-34-8
Molecular Formula:C₂₅H₄₀N₂O₅
Molecular Weight:448.603
Hs Code.:

Synonyms:(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

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Chemical Property of (2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

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Technology Process of (2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

There total 9 articles about (2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 656241-34-8
(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / NaBH₄ / methanol / 1 h / 20 °C

2.1: 100 percent / Me₃SiBr / 0.17 h / 20 °C

3.1: LiHMDS / tetrahydrofuran / 1.25 h / -70 °C

3.2: 33 g / tetrahydrofuran / 18 h / 0 °C

4.1: 94 percent / 30 percent aq H₂O₂; LiOH / tetrahydrofuran; H₂O / 3 h / 20 °C

5.1: NaBH₄ / tetrahydrofuran / 0.75 h / 20 °C

5.2: 100 percent / I₂ / tetrahydrofuran / 96 h / 20 °C

6.1: 100 percent / NBS; Ph₃P / CH₂Cl₂ / 18 h / 20 °C

7.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -40 °C

7.2: tetrahydrofuran / 18 h / -20 °C

With lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; trimethylsilyl bromide; dihydrogen peroxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1002/hlca.200390235

Reference yield:

: 38629-19-5
3,6-Diethoxy-2,5-dihydropyridazin

: 656241-30-4
(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide

: 656241-34-8
(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

: (2S)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

Guidance literature:: 3,6-Diethoxy-2,5-dihydropyridazin; With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃; for 0.25h;

(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide; In tetrahydrofuran; at -20 ℃; for 18h;
DOI:10.1002/hlca.200390235

Reference yield:

: 621-59-0
isovanillin

: 656241-34-8
(2R)-3,6-diethoxy-2,5-dihydro-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 93 percent / K₂CO₃ / acetonitrile / 19 h / Heating

2.1: 72 percent / NaOMe / methanol / 1.5 h / Heating

3.1: 96 percent / NaBH₄ / methanol / 1 h / 20 °C

4.1: 100 percent / Me₃SiBr / 0.17 h / 20 °C

5.1: LiHMDS / tetrahydrofuran / 1.25 h / -70 °C

5.2: 33 g / tetrahydrofuran / 18 h / 0 °C

6.1: 94 percent / 30 percent aq H₂O₂; LiOH / tetrahydrofuran; H₂O / 3 h / 20 °C

7.1: NaBH₄ / tetrahydrofuran / 0.75 h / 20 °C

7.2: 100 percent / I₂ / tetrahydrofuran / 96 h / 20 °C

8.1: 100 percent / NBS; Ph₃P / CH₂Cl₂ / 18 h / 20 °C

9.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -40 °C

9.2: tetrahydrofuran / 18 h / -20 °C

With lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; trimethylsilyl bromide; dihydrogen peroxide; sodium methylate; potassium carbonate; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.200390235