N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Base Information

Chemical Name:N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide
CAS No.:75792-53-9
Molecular Formula:C₂₈H₃₆N₄O₅
Molecular Weight:508.618
Hs Code.:

Synonyms:N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Suppliers and Price of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

There total 11 articles about N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 77153-23-2
hydroxybenzotriazolide of 3-<(tert-butoxycarbonyl)amino>-5-carboxy-1,2,4-trimethylpyrrole

: 75792-44-8
benzyl 4-amino-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-53-9
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: With acetic acid; In N,N-dimethyl-formamide; 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight;
DOI:10.1021/jm00133a008

Reference yield:

: 7473-16-7
ethyl 4-carboxy-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-53-9
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NaH / 90 °C / 10 Torr

2: 75 percent / diphenylphosphoryl azide (DPPA), Et₃N / acetonitrile / 1.5 h / 50 °C

3: 95 percent / CuCl / 5 h / 60 °C

4: H₂ / 10percent Pd/C / dioxane / 12 h

5: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

6: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

With diphenylphosphoranyl azide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hydride; acetic acid; triethylamine; copper(l) chloride; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008

Reference yield:

: 75792-41-5
ethyl 4-isocyanato-1,3,5-trimethylpyrrole-2-carboxylate

: 75792-53-9
N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / acetonitrile / 5 h / 50 °C

2: H₂ / 10percent Pd/C / methanol

3: 100 percent / Na / 4 h / 100 °C

5: H₂ / 10percent Pd/C / dioxane / 12 h

6: Et₃N, 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 0.25 h / 0 °C

7: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008