methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

Base Information

Chemical Name:methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate
CAS No.:291533-86-3
Molecular Formula:C₂₅H₂₃NO₄S₂
Molecular Weight:465.594
Hs Code.:

Synonyms:methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

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Chemical Property of methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

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Technology Process of methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

There total 5 articles about methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 291533-77-2
(+/-)-methyl 2-(4-iodobenzenesulfonylamino)-5-phenylpent-4-ynoate

: 291533-86-3
methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; benzene; Heating;
DOI:10.1021/jm000477l

Reference yield:

: 71460-02-1,173306-82-6
methyl 2-[((1,1-dimethylethoxy)carbonyl)amino]-4-pentynoate

: 291533-86-3
methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Et₃N; (Ph₃P)4Pd; CuI / dimethylformamide / 18 h / 20 °C

2: SOCl₂ / methanol / 1 h / 20 °C

3: 3.9 g / Et₃N / dioxane; H₂O / 18 h

4: 67 percent / aq. Na₂CO₃; Pd(PPh₃)4 / benzene; methanol / Heating

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; benzene; 3: Schotten-Baumann reaction / 4: Suzuki coupling;
DOI:10.1021/jm000477l

Reference yield:

: 70837-20-6
propargyclycine methyl ester hydrochloride

: 291533-86-3
methyl 2-{[4'-thiomethoxy(1,1'-biphenyl)-4-yl]sulfonyl}amino-5-phenylpent-4-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1: 9.6 g / Et₃N / CH₂Cl₂ / 18 h

2: 72 percent / Et₃N; (Ph₃P)4Pd; CuI / dimethylformamide / 18 h / 20 °C

3: SOCl₂ / methanol / 1 h / 20 °C

4: 3.9 g / Et₃N / dioxane; H₂O / 18 h

5: 67 percent / aq. Na₂CO₃; Pd(PPh₃)4 / benzene; methanol / Heating

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene; 4: Schotten-Baumann reaction / 5: Suzuki coupling;
DOI:10.1021/jm000477l