2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

Base Information

Chemical Name:2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate
CAS No.:1374561-15-5
Molecular Formula:C₁₈H₁₃F₆NO₃
Molecular Weight:405.297
Hs Code.:

Synonyms:2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

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Chemical Property of 2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

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Technology Process of 2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

There total 4 articles about 2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1374561-32-6
2-[2,2-difluoro-2-(phenylsulfonyl)ethylamino]-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

: 1374561-15-5
2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

Guidance literature:: With sodium acetate; magnesium; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/ejoc.201101518

Reference yield: 85.0%

: 1374560-97-0
2-[2,2-difluoro-2-(phenylthio)ethylamino]-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

: 1374561-15-5
2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 8h; Inert atmosphere; Reflux;
DOI:10.1002/ejoc.201101518

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 1374561-15-5
2-(2,2-difluoroethylamino)-1-[3-fluoro-4-(trifluoromethyl)phenyl]-2-oxoethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 20 °C / Neat (no solvent)

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 8 h / Inert atmosphere; Reflux

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; 1: Passerini reaction;
DOI:10.1002/ejoc.201101518