2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Base Information

• Chemical Name: 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
• CAS No.: 870073-17-9
• Molecular Formula: C₂₄H₃₉N₃O₂
• Molecular Weight: 406.553

Synonyms:2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Chemical Property of 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Chemical Property:

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Technology Process of 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

There total 3 articles about 2-(3-amino-2-hydoxy-4-[2H₅]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C29H42(2)H5N3O4 (870073-16-8) → 2-(3-amino-2-hydoxy-4-[2H5]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide (870073-17-9)

Guidance literature:

With methanesulfonic acid; In Isopropyl acetate; at 85 ℃;

DOI:10.1002/jlcr.913

Reference yield:

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide (128019-40-9,149510-73-6,136465-81-1,168899-60-3) → 2-(3-amino-2-hydoxy-4-[2H5]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide (870073-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / propan-2-ol / 4 h / Heating

2: 78 percent / methanesulfonic acid / isopropyl acetate / 85 °C

With methanesulfonic acid; In Isopropyl acetate; isopropyl alcohol;

DOI:10.1002/jlcr.913

Reference yield:

(1S,2S)-(oxiranyl-2-[2H5]-phenyl-ethyl)-carbamic acid tert-butyl ester (856765-76-9) → 2-(3-amino-2-hydoxy-4-[2H5]phenyl-butyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide (870073-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / propan-2-ol / 4 h / Heating

2: 78 percent / methanesulfonic acid / isopropyl acetate / 85 °C

With methanesulfonic acid; In Isopropyl acetate; isopropyl alcohol;

DOI:10.1002/jlcr.913

upstream raw materials:

C₂₉H₄₂⁽²⁾H₅N₃O₄

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

(1S,2S)-(oxiranyl-2-[2H₅]-phenyl-ethyl)-carbamic acid tert-butyl ester

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