2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate

Base Information

• Chemical Name: 2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate
• CAS No.: 1029347-55-4
• Molecular Formula: C₃₄H₃₇N₆O₉P
• Molecular Weight: 704.676

Synonyms:2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate

Chemical Property of 2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate

Chemical Property:

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Technology Process of 2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate

There total 1 articles about 2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate (906670-24-4) + 2',3'-O,O-isopropylidene-2'-C-β-methylguanosine (1029347-56-5) → 2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate (1029347-55-4)

Guidance literature:

2',3'-O,O-isopropylidene-2'-C-β-methylguanosine; With tert-butylmagnesium chloride; In tetrahydrofuran; Inert atmosphere;

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm1003792

Reference yield: 28.0%

2',3'-O,O-isopropylidene-β-2'-methyl-guanosine 5'-O-[α-naphthyl(benzoxy-L-alaninyl)] phosphate (1029347-55-4) → (2S)-benzyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propanoate (1029347-57-6)

Guidance literature:

With acetic acid; In water; at 90 ℃; for 15h;

DOI:10.1016/j.bmcl.2009.05.122

upstream raw materials:

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate

2',3'-O,O-isopropylidene-2'-C-β-methylguanosine

Downstream raw materials:

(2S)-benzyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propanoate

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