2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

Base Information

Chemical Name:2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide
CAS No.:552888-96-7
Molecular Formula:C₂₃H₃₀BrNO₄
Molecular Weight:464.399
Hs Code.:

Synonyms:2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

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Chemical Property of 2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

Chemical Property:

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Technology Process of 2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

There total 6 articles about 2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-propionyl chloride

: 552888-96-7
2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

Guidance literature:: With ammonia; In formamide; for 1h;
DOI:10.3390/71000743

Reference yield:

: 40141-12-6
1-(Chloromethyl)-4-(1-methylethoxy)benzene

: 552888-96-7
2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / anhydrous potassium carbonate / dimethylformamide / 24 h / 70 °C

2: 82 percent / anhydrous potassium carbonate / acetonitrile / 24 h / 60 °C

3: KOH / ethanol; H₂O / 12 h / Heating

4: 0.5 h / 160 °C

5: thionyl chloride / dimethylformamide / 6 h / 20 °C

6: 2.58 g / NH₃ / formamide / 1 h

With potassium hydroxide; thionyl chloride; ammonia; potassium carbonate; In ethanol; water; formamide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.3390/71000743

Reference yield:

: 365572-34-5
2-[4-(1-methylethoxy)phenylmethyl]propanedioic acid dimethyl ester

: 552888-96-7
2-bromo-4-methoxy-5-(1-methylethoxy)-α-[[4-(1-methylethoxy)phenyl]methyl]benzenepropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / anhydrous potassium carbonate / acetonitrile / 24 h / 60 °C

2: KOH / ethanol; H₂O / 12 h / Heating

3: 0.5 h / 160 °C

4: thionyl chloride / dimethylformamide / 6 h / 20 °C

5: 2.58 g / NH₃ / formamide / 1 h

With potassium hydroxide; thionyl chloride; ammonia; potassium carbonate; In ethanol; water; formamide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.3390/71000743