Technology Process of C22H18N4O4
There total 4 articles about C22H18N4O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1016/j.tet.2012.07.093
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium bromide / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere
2.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere
2.2: 6 h / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
With
caesium carbonate; trifluoroacetic acid; lithium bromide;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.07.093
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); N-butylamine / 80 - 85 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
3.1: lithium bromide / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere
4.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere
4.2: 6 h / 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); caesium carbonate; N-butylamine; triethylamine; trifluoroacetic acid; lithium bromide;
In
tetrahydrofuran; dichloromethane; acetonitrile;
1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.07.093
