1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Chemical Name:1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide
CAS No.:1449320-39-1
Molecular Formula:C₃₁H₃₂N₆O₂
Molecular Weight:520.634
Hs Code.:

Synonyms:1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Chemical Property of 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

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Technology Process of 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

There total 8 articles about 1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: C₃₈H₃₈N₆O₄S

: 1449320-39-1
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: C₃₈H₃₈N₆O₄S; With potassium carbonate; In methanol; at 100 ℃; for 0.5h; Microwave irradiation;

With water; In methanol;

Reference yield: 38.0%

: 1449320-39-1
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: With methanol; potassium carbonate; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1449318-35-7
1-benzyl-1H-pyrazol-4-carboxylic acid (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: 1449320-39-1
1-benzyl-1H-pyrazol-4-carboxylic acid {5-[3-(1-methylpiperidin-3-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}amide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 4 h / 20 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 70 °C

4: potassium carbonate / methanol / 0.5 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;