N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

Base Information

Chemical Name:N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline
CAS No.:1609565-00-5
Molecular Formula:C₂₅H₃₂N₄O₃S
Molecular Weight:468.62
Hs Code.:

Synonyms:N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

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Chemical Property of N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

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Technology Process of N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

There total 7 articles about N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1609564-71-7
1-isopropyl-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

: 1609565-00-5
N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: 1242014-95-4
ethyl 3-(p-tolyl)-1H-pyrazole-4-carboxylate

: 1609565-00-5
N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: potassium hydroxide / water; ethanol / 2.5 h / 75 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere

4: borane-THF / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

With dmap; borane-THF; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: C₁₆H₂₀N₂O₂

: 1609565-00-5
N-((1-isopropyl-3-(p-tolyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water; ethanol / 2.5 h / 75 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: borane-THF / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

With dmap; borane-THF; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014