5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

Base Information

Chemical Name:5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide
CAS No.:346671-59-8
Molecular Formula:C₂₃H₂₄N₄O₆S
Molecular Weight:484.533
Hs Code.:

Synonyms:5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

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Chemical Property of 5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

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Technology Process of 5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

There total 4 articles about 5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 346671-59-8
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe / methanol / 18 h / 20 °C

2: POCl₃; PhNMe₂ / 120 °C

3: dimethylsulfoxide / 20 - 60 °C

4: Heating

With sodium methylate; N,N-dimethyl-aniline; trichlorophosphate; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 150727-22-3
5-(o-methoxyphenoxy)-4,6-dihydroxy-pyrimidine

: 346671-59-8
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃; PhNMe₂ / 120 °C

2: dimethylsulfoxide / 20 - 60 °C

3: Heating

With N,N-dimethyl-aniline; trichlorophosphate; In dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 150727-23-4
4,6-dichloro-5-(o-methoxyphenoxy)-pyrimidine

: 346671-59-8
5-isopropyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfoxide / 20 - 60 °C

2: Heating

In dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3