N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

Base Information

Chemical Name:N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide
CAS No.:1621694-35-6
Molecular Formula:C₄₀H₄₃Cl₂N₅O
Molecular Weight:680.72
Hs Code.:

Synonyms:N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

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Chemical Property of N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

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Technology Process of N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

There total 3 articles about N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621694-43-6
C₄₅H₅₁Cl₂N₅O₃

: 1621694-35-6
N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2014.07.021

Reference yield:

: 1567847-49-7
ethyl 1-(tert-butoxycarbonyl)-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxylate

: 1621694-35-6
N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / methanol / 24 h / Reflux

1.2: 0.5 h

2.1: N,N-dimethyl-formamide; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / ethyl acetate / 0.08 h / 20 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1016/j.ejmech.2014.07.021

Reference yield:

: 1567847-47-5
C₂₄H₂₃ClN₂O₄*ClH

: 1621694-35-6
N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-5-(4-chlorophenyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-9-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / ethyl acetate / 0.08 h / 20 °C

1.2: 18 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; ethyl acetate;
DOI:10.1016/j.ejmech.2014.07.021