threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate
CAS No.:1384275-34-6
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

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Chemical Property of threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

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Technology Process of threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

There total 15 articles about threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

: 1384275-34-6
threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

: 1384275-32-4
C₂₇H₃₂N₂O₄

Guidance literature:: With CHIRALPAK IA; In hexane; diethylamine; isopropyl alcohol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 19287-55-9
(2-(4-methoxyphenyl)quinolin-4-yl)-(piperidin-2-yl)methanol

: 1384275-34-6
threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

: 1384275-41-5
erythro-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm300117u

Reference yield:

: 1369590-97-5
(2-(4-methoxyphenyl)quinolin-4-yl)(pyridin-2-yl)methanone

: 1384275-34-6
threo-tert-butyl 2-(hydroxy(2-(4-methoxyphenyl)quinolin-4-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 0 °C

2: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 2 h / 20 °C

3: triethylamine / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jm300117u