(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Base Information

Chemical Name:(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester
CAS No.:913288-79-6
Molecular Formula:C₃₁H₃₇NO₄S₂
Molecular Weight:551.771
Hs Code.:

Synonyms:(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Suppliers and Price of (2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

There total 10 articles about (2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 913288-78-5
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolpropionate

: 107-02-8,25068-14-8
acrolein

: 3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

: 913288-79-6
(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Guidance literature:: With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 - 0 ℃; for 3h;
DOI:10.1021/ol0614774

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 913288-79-6
(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 87 percent / methanesulfonylchloride; Et₃N / 14.17 h / 0 - 20 °C

3: 93 percent / PBu₃ / acetonitrile; H₂O / 18 h / 20 °C

4: NaH / dimethylformamide / 18 h / 20 °C

5: 96 percent / NaOMe / methanol / 1.5 h / 20 °C

6: 83 percent / pyridine / CH₂Cl₂ / 18 h / 0 - 20 °C

7: 92 percent / dicyclohexylboron triflate; Et₃N / CH₂Cl₂; hexane / 3 h / -78 - 0 °C

With pyridine; tributylphosphine; sodium methylate; sodium hydride; methanesulfonyl chloride; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0614774

Reference yield:

: 913288-78-5
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolpropionate

: 107-02-8,25068-14-8
acrolein

: 913288-79-6
(2S,3S)-3-Hydroxy-2-methyl-pent-4-enethioic acid S-{(1S,2R)-2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl} ester

: 3-hydroxy-2-methyl-pent-4-enethioic acid 2-[benzyl-(2,4,6-trimethyl-benzenesulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: (1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolpropionate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 2h;

acrolein; In hexane; dichloromethane; at -78 - 0 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1021/ol062932z