C₄₈H₇₆O₇Si₃

Base Information

• Chemical Name: C₄₈H₇₆O₇Si₃
• CAS No.: 1255639-79-2
• Molecular Formula: C₄₈H₇₆O₇Si₃
• Molecular Weight: 849.384
• Mol file: 1255639-79-2.mol

Synonyms:C₄₈H₇₆O₇Si₃

Chemical Property of C₄₈H₇₆O₇Si₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₇₆O₇Si₃

There total 7 articles about C₄₈H₇₆O₇Si₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C48H74O7Si3 (1255639-78-1) → C48H76O7Si3 (1255639-79-2)

Guidance literature:

With hydrogen; In ethyl acetate; for 0.833333h; under 5625.56 Torr; Inert atmosphere;

DOI:10.1021/ml1001807

Reference yield:

(S)-1-(tert-butyldimethylsiloxy)-3-(tert-butyldiphenylsiloxy)hex-5-ene (1255639-72-5) → C48H76O7Si3 (1255639-79-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: water; toluene-4-sulfonic acid / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / -78 - -10 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

5.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

5.3: 19 h / Inert atmosphere; Reflux

6.1: hydrogen / ethyl acetate / 0.83 h / 5625.56 Torr / Inert atmosphere

With 1H-imidazole; n-butyllithium; oxalyl dichloride; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2.1: Swern oxidation / 2.2: Swern oxidation / 5.1: Suzuki Miyaura coupling / 5.2: Suzuki Miyaura coupling / 5.3: Suzuki Miyaura coupling;

DOI:10.1021/ml1001807

Reference yield:

C33H50O3Si2 (1255639-76-9) → C48H76O7Si3 (1255639-79-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: 19 h / Inert atmosphere; Reflux

3.1: hydrogen / ethyl acetate / 0.83 h / 5625.56 Torr / Inert atmosphere

With 1H-imidazole; hydrogen; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2.1: Suzuki Miyaura coupling / 2.2: Suzuki Miyaura coupling / 2.3: Suzuki Miyaura coupling;

DOI:10.1021/ml1001807

upstream raw materials:

(S)-1-(tert-butyldimethylsiloxy)-3-(tert-butyldiphenylsiloxy)hex-5-ene

(S)-3-(tert-butyldiphenylsiloxy)hex-5-en-1-ol

C₂₂H₂₈O₂Si

C₃₃H₅₀O₃Si₂

Downstream raw materials:

C₄₁H₅₈O₆Si₂

C₃₅H₄₂O₆Si

C₃₅H₄₂O₆Si