N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

Base Information

Chemical Name:N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide
CAS No.:1309960-65-3
Molecular Formula:C₂₁H₁₇N₃O₃S
Molecular Weight:391.45
Hs Code.:

Synonyms:N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

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Chemical Property of N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

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Technology Process of N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

There total 10 articles about N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: N-{2-[(2,4-dimethoxybenzyl)amino]-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}methanesulfonamide

: 1309960-65-3
N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm200112k

Reference yield:

: 917881-59-5
N-(methylsulfonyl)-N-(5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

: 1309960-65-3
N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / Inert atmosphere

2: trichlorophosphate / 0.5 h / 90 °C / Inert atmosphere

3: isopropyl alcohol / 48 h / 85 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; ethyl acetate / 80 °C / Inert atmosphere

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In 1,4-dioxane; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm200112k

Reference yield:

: 7-[(2,4-dimethoxybenzyl)amino]-3-phenyl-5H-5Hbenzo[4,5]cyclohepta[1,2-b]pyridin-5-one

: 1309960-65-3
N-(2-amino-5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / methanol; dichloromethane / 1 h / 40 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / Inert atmosphere

4: trichlorophosphate / 0.5 h / 90 °C / Inert atmosphere

5: isopropyl alcohol / 48 h / 85 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; ethyl acetate / 80 °C / Inert atmosphere

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm200112k