methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate

Base Information

• Chemical Name: methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate
• CAS No.: 503613-32-9
• Molecular Formula: C₂₆H₁₉F₄N₃O₅
• Molecular Weight: 529.448
• Mol file: 503613-32-9.mol

Synonyms:methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate

Chemical Property of methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate

There total 10 articles about methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-fluoro-4-iodo phenyl acetic acid methyl ester (345963-98-6) + 2,2-dimethylpropanoic 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic anhydride → methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate (503613-32-9)

Guidance literature:

2-fluoro-4-iodo phenyl acetic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.333333h;

2,2-dimethylpropanoic 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic anhydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 23 ℃; for 2h;

Reference yield: 49.0%

→ methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate (503613-32-9)

Guidance literature:

Reference yield:

methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate (503614-64-0) → methyl 2-[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]-3-[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-oxopropanoate (503613-32-9)

Guidance literature:

With n-butyllithium; 4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.11.040

upstream raw materials:

methyl [2-fluoro-4-(2-oxo-1(2H)-pyridinyl)-phenyl]acetate

4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

5-(furan-2-yl)-1-(4-methoxyphenyl )-3-(trifluoromethyl )-1H-pyrazole

1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid