N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

Base Information

Chemical Name:N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide
CAS No.:1428764-42-4
Molecular Formula:C₂₃H₂₂F₄N₄O₃S
Molecular Weight:510.512
Hs Code.:

Synonyms:N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

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Chemical Property of N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

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Technology Process of N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

There total 10 articles about N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1402586-13-3
phenyl 3-fluoro-4-(methylsulfonamidomethyl)phenylcarbamate

: 1428765-32-5
(2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1428764-42-4
N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

Guidance literature:: With dmap; In acetonitrile; at 50 ℃; for 15h;

Reference yield:

: 386704-06-9
2-chloro-6-(trifluoromethyl)nicotinonitrile

: 1428764-42-4
N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / 5250.53 Torr / Inert atmosphere; Microwave irradiation

2: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr

3: dmap / acetonitrile / 15 h / 50 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; In methanol; ethanol; water; toluene; acetonitrile;

Reference yield:

: 17933-03-8
m-tolylboronic acid

: 1428764-42-4
N-(2-fluoro-4-(3-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / 5250.53 Torr / Inert atmosphere; Microwave irradiation

2: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr

3: dmap / acetonitrile / 15 h / 50 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; In methanol; ethanol; water; toluene; acetonitrile;