1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

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Chemical Name:1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine
CAS No.:845440-30-4
Molecular Formula:C₄₇H₇₅NO₄SSi₃
Molecular Weight:834.439
Hs Code.:

1-[2-(4-{[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10<i>H</i>-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

Synonyms:1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

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Chemical Property of 1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

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Technology Process of 1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

There total 14 articles about 1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 845439-81-8
[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

: 845440-30-4
1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/ol047741f

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 845440-30-4
1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / boron tribromide / 20 °C

2: LAH / tetrahydrofuran / 0 °C

3: TFA; Et₃SiH

4: 100 percent / Et₃N

5: sec-BuLi / tetrahydrofuran / -78 °C

6: 90 percent / Et₃N / CH₂Cl₂

With triethylsilane; lithium aluminium tetrahydride; sec.-butyllithium; boron tribromide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol047741f

Reference yield:

: 108-46-3
recorcinol

: 845440-30-4
1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

Guidance literature:: Multi-step reaction with 13 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

3.1: 75 percent / NaH; DMAP

4.1: 75 percent / diphenyl ether / 4 h / 280 °C

5.1: NaOH / methanol

5.2: 100 percent / aq. HCl

6.1: boron tribromide / 0 °C

7.1: 80 percent / boron tribromide / 20 °C

8.1: LAH / tetrahydrofuran / 0 °C

9.1: TFA; Et₃SiH

10.1: 100 percent / Et₃N

11.1: sec-BuLi / tetrahydrofuran / -78 °C

12.1: 90 percent / Et₃N / CH₂Cl₂

With triethylsilane; dmap; sodium hydroxide; lithium aluminium tetrahydride; trimethylaluminum; sec.-butyllithium; boron tribromide; sodium hydride; copper(II) sulfate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diphenylether; dichloromethane; 4.1: Newman-Kwart rearrangement;
DOI:10.1021/ol047741f