tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

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Chemical Name:tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate
CAS No.:1391999-78-2
Molecular Formula:C₃₇H₅₂N₂O₉
Molecular Weight:668.828
Hs Code.:

Synonyms:tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

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Chemical Property of tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

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Technology Process of tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

There total 10 articles about tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1391999-76-0
tert-butyl 3-(3-isocyanato-4-isopropoxyphenyl)propanoate

: 1391999-68-0
tert-butyl 2-(3-(but-3-en-1-ylcarbamoyl)-5-isopropoxyphenoxy)acetate

: 1391999-78-2
tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

Guidance literature:: tert-butyl 2-(3-(but-3-en-1-ylcarbamoyl)-5-isopropoxyphenoxy)acetate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.25h; Inert atmosphere;

tert-butyl 3-(3-isocyanato-4-isopropoxyphenyl)propanoate; With acetic acid; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2ob25273b

Reference yield:

: 1391999-64-6
benzyl 3-hydroxy-5-isopropoxybenzoate

: 1391999-78-2
tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 90 °C / Inert atmosphere

2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

With oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob25273b

Reference yield:

: 1391999-74-8
tert-butyl 3-(4-isopropoxy-3-nitrophenyl)acrylate

: 1391999-78-2
tert-butyl 3-(3-(3-(but-3-en-1-yl)-3-(3-(2-(tert-butoxy)-2-oxoethoxy)-5-isopropoxybenzoyl)ureido)-4-isopropoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 14 h / Inert atmosphere

2.1: sodium hydrogencarbonate / dichloromethane; water / 0.83 h / 20 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; potassium hexamethylsilazane; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1039/c2ob25273b