Technology Process of Acetic acid (2R,3R,4S,5S,6R)-5-acetoxy-4-benzyloxycarbonylamino-2-(bis-benzyloxy-phosphoryloxy)-6-methyl-tetrahydro-pyran-3-yl ester
There total 15 articles about Acetic acid (2R,3R,4S,5S,6R)-5-acetoxy-4-benzyloxycarbonylamino-2-(bis-benzyloxy-phosphoryloxy)-6-methyl-tetrahydro-pyran-3-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
1: NaBH4 / ethanol
2: pyridine
3: NaN3, 15-crown-5
4: LiAlH4 / diethyl ether
5: Na2CO3
6: 60percent aq. AcOH / 60 °C
7: pyridine
8: NaI / acetone
9: NaBH4 / bis-(2-methoxy-ethyl) ether
10: 0.1 N aq. HCl
11: pyridine
12: NH2NH2, AcOH
13: 1H-tetrazole
14: m-CPBA
With
pyridine; 1H-tetrazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; 15-crown-5; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; hydrazine;
In
diethyl ether; ethanol; diethylene glycol dimethyl ether; acetone;
DOI:10.1021/ja9815881
- Guidance literature:
-
Multi-step reaction with 12 steps
1: NaN3, 15-crown-5
2: LiAlH4 / diethyl ether
3: Na2CO3
4: 60percent aq. AcOH / 60 °C
5: pyridine
6: NaI / acetone
7: NaBH4 / bis-(2-methoxy-ethyl) ether
8: 0.1 N aq. HCl
9: pyridine
10: NH2NH2, AcOH
11: 1H-tetrazole
12: m-CPBA
With
pyridine; 1H-tetrazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; 15-crown-5; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; hydrazine;
In
diethyl ether; diethylene glycol dimethyl ether; acetone;
DOI:10.1021/ja9815881
- Guidance literature:
-
Multi-step reaction with 11 steps
1: LiAlH4 / diethyl ether
2: Na2CO3
3: 60percent aq. AcOH / 60 °C
4: pyridine
5: NaI / acetone
6: NaBH4 / bis-(2-methoxy-ethyl) ether
7: 0.1 N aq. HCl
8: pyridine
9: NH2NH2, AcOH
10: 1H-tetrazole
11: m-CPBA
With
pyridine; 1H-tetrazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; hydrazine;
In
diethyl ether; diethylene glycol dimethyl ether; acetone;
DOI:10.1021/ja9815881