6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1065081-82-4
Molecular Formula:C₁₇H₁₆Cl₂N₄OS
Molecular Weight:395.312
Hs Code.:

Synonyms:6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of 6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of 6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 3 articles about 6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 18542-42-2
(2-aminoethyl)methylsulfide

: 1065081-55-1
6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1065081-82-4
6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1065081-82-4
6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / hexanes; dichloromethane / 3.5 h / -78 °C

2.2: 0.33 h

2.3: 20 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

With sodium hydride; diisobutylaluminium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 146821-47-8
dimethyl 2-(3,4-dichlorobenzyl)malonate

: 1065081-82-4
6-(3,4-dichlorobenzyl)-N-[2-(methylthio)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / hexanes; dichloromethane / 3.5 h / -78 °C

1.2: 0.33 h

1.3: 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

With diisobutylaluminium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In hexanes; dichloromethane; N,N-dimethyl-formamide;