4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

Base Information

Chemical Name:4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole
CAS No.:1070787-55-1
Molecular Formula:C₁₆H₁₉N₃O₄S
Molecular Weight:349.411
Hs Code.:

Synonyms:4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

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Chemical Property of 4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

Chemical Property:

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Technology Process of 4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

There total 2 articles about 4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070779-73-5
3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid

: 33641-15-5
1-methyl-5-hydroxypyrazole

: 1070787-55-1
4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

Guidance literature:: 3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid; 1-methyl-5-hydroxypyrazole; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 5h;

With trimethylsilyl cyanide; potassium cyanide; triethylamine; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 118939-18-7
3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid

: 1070787-55-1
4-[3-cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoyl]-5-hydroxy-1-methylpyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 24 h / 120 °C

1.2: 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 5 h / 20 °C

2.2: 24 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;