(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

Base Information

Chemical Name:(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester
CAS No.:261963-29-5
Molecular Formula:C₂₈H₂₇NO₇
Molecular Weight:489.525
Hs Code.:

Synonyms:(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

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Chemical Property of (-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

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Technology Process of (-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

There total 1 articles about (-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 32807-28-6,935731-94-5
Methyl 4-chloroacetoacetate

: (-)-(R)-(phenyl)[(phenylmethoxycarbonyl)(phenylmethyl)amino]acetic acid potassium salt

: 261963-29-5
(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

: 261963-29-5
(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

: 261963-30-8
(E)-[(6-oxo-5R-phenyl-4-phenylmethyl)morpholin-3-yliden]acetic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid methyl ester; at 20 ℃; for 6h; under 760 Torr;
DOI:10.1016/S0040-4020(99)00935-7

Reference yield:

: 261963-29-5
(-)-3-oxo-4-[(R)-(phenyl)((phenylmethoxycarbonyl)(phenylmethyl)amino)acetoxy] butanoic acid methyl ester

: 196937-33-4
(2S)-[(2-hydroxy-(1R)-phenyl)ethylamino]butan-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / Pd/C / methyl acetate / 6 h / 20 °C / 760 Torr

2: 71 percent / sodium borohydride; glacial acetic acid / acetonitrile / 10 °C

3: 64 percent / hydrogen / Pd/C / methyl acetate / 20 h / 20 °C / 760 Torr

4: 38 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; acetic acid methyl ester; acetonitrile; 1: Hydrogenolysis / 2: Reduction / 3: Hydrogenolysis / 4: Ring cleavage;
DOI:10.1016/S0040-4020(99)00935-7