Ald-PEG3-Azide

Base Information

• Chemical Name: Ald-PEG3-Azide
• CAS No.: 1002342-83-7
• Molecular Formula: C₈H₁₅N₃O₄
• Molecular Weight: 217.225
• Mol file: 1002342-83-7.mol

Synonyms:2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)acetaldehyde

Chemical Property of Ald-PEG3-Azide

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ald-PEG3-azide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Ald-CH2-PEG3-azide is a click chemistry PEG linker. Aldehyde groups are likely to undergo nucleophile substitution, reduction and oxidation reactions. The azideN3 enable Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. PEG3 spacer increases the water solubility of the compound.

Technology Process of Ald-PEG3-Azide

There total 1 articles about Ald-PEG3-Azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) → 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)acetaldehyde (1002342-83-7)

Guidance literature:

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol; With oxalyl dichloride; In tetrahydrofuran; dimethyl sulfoxide; at -78 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; dimethyl sulfoxide; at -78 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/chem.202002432

Reference yield: 81.0%

2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)acetaldehyde (1002342-83-7) + C21H24ClFN6O2*2C2HF3O2 → C29H39ClFN9O5*2C2HF3O2

Guidance literature:

With sodium cyanoborohydride; In methanol; ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/acschembio.0c00888

upstream raw materials:

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

Refernces

• 1、 Rubinshtein, Mark,James, Carrie R.,Young, Jennifer L.,Ma, Yanyan J.,Kobayashi, Yoshihisa,Gianneschi, Nathan C.,Yang, Jerry. "Facile procedure for generating side chain functionalized poly(α-hydroxy acid) copolymers from aldehydes via a versatile passerini-type condensation". . p. 3560 - 3563. Retrieved 2010.
• 2、 Park, Ki Duk,Liu, Rihe,Kohn, Harold. "Useful Tools for Biomolecule Isolation, Detection, and Identification: Acylhydrazone-Based Cleavable Linkers". experimental part. p. 763 - 772. Retrieved 2010/04/22.