4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

Base Information

Chemical Name:4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide
CAS No.:1436421-36-1
Molecular Formula:C₂₆H₃₀ClF₄N₅O
Molecular Weight:540.004
Hs Code.:

Synonyms:4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

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Chemical Property of 4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

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Technology Process of 4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

There total 5 articles about 4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,5-diazabicyclo[2.2.1]heptane dihydrobromide

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 477199-77-2
4-(bromomethyl)-2-fluorobenzoic acid

: 1436421-36-1
4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

Guidance literature:: 4-(bromomethyl)-2-fluorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

2,5-diazabicyclo[2.2.1]heptane dihydrobromide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436421-36-1
4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3.1: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 0.5 h / 80 °C

With oxalyl dichloride; ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 7697-23-6
2-fluoro-4-methylbenzoic Acid

: 1436421-36-1
4-(2,5-diazabicyclo[2.2.1]heptan-2-ylmethyl)-N-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenyl)-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 100 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 0.5 h / 20 °C

2.3: 0.5 h / 80 °C

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;