(5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one

Base Information

Chemical Name:(5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one
CAS No.:127227-42-3
Molecular Formula:C₂₄H₂₀N₆O₃S₂
Molecular Weight:504.593
Hs Code.:
Mol file:127227-42-3.mol

Synonyms:Ethanethioicacid, [(4-methoxyphenyl)amino]-,S-[5-[4,5-dihydro-4-(1H-indol-3-ylmethylene)-2-methyl-5-oxo-1H-imidazol-1-yl]-1,3,4-thiadiazol-2-yl]ester (9CI)

Suppliers and Price of (5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of (5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one

Chemical Property:

Vapor Pressure:5.36E-24mmHg at 25°C
Boiling Point:775.7°Cat760mmHg
Flash Point:422.9°C
PSA：166.11000
Density:1.49g/cm³
LogP:4.13850

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one

There total 3 articles about (5E)-5-(1H-indol-3-ylmethylidene)-3-[5-[2-[(4-methoxyphenyl)amino]acet yl]sulfanyl-1,3,4-thiadiazol-2-yl]-2-methyl-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 127227-48-9
(4-Methoxy-phenylamino)-acetyl chloride

: 127227-36-5
3-<4'-(1''H-indol-3''-ylmethylene)-2'-methyl-5'-(4'H)-oxo-1'H-imidazol-1'-yl>-5-mercapto-1,3,4-thiadiazole

: 127227-42-3
(4-Methoxy-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: With potassium carbonate; In acetone; for 4h; Heating;

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 127227-42-3
(4-Methoxy-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / sodium acetate, acetic anhydride / 2 h / Heating

2: 70 percent / 0.33 h / 140 °C / Heating

3: 62 percent / K₂CO₃ / acetone / 4 h / Heating

With sodium acetate; acetic anhydride; potassium carbonate; In acetone;

Reference yield:

: 54753-57-0,70082-68-7,70082-69-8
4-(1'H-indol-3'-ylmethylene)-2-methyl-5(4H)oxazolone

: 127227-42-3
(4-Methoxy-phenylamino)-thioacetic acid S-(5-{4-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-[1,3,4]thiadiazol-2-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 0.33 h / 140 °C / Heating

2: 62 percent / K₂CO₃ / acetone / 4 h / Heating

With potassium carbonate; In acetone;