2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

Base Information

Chemical Name:2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone
CAS No.:189885-42-5
Molecular Formula:C₂₄H₂₅NO₂S
Molecular Weight:391.534
Hs Code.:

Synonyms:2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

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Chemical Property of 2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

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Technology Process of 2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

There total 3 articles about 2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 16191-72-3
N-Benzyl-β-tosylethylamine

: 91-13-4
α,α'-dibromo-o-xylene

: 189885-42-5
2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

Guidance literature:: N-Benzyl-β-tosylethylamine; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

α,α'-dibromo-o-xylene; In tetrahydrofuran; hexane; at -78 - -70 ℃;
DOI:10.1016/S0040-4020(97)00163-4

Reference yield:

: 5535-52-4
tolyl vinyl sulfone

: 189885-42-5
2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / tetrahydrofuran / 6 h / Heating

2.1: n-butyllithium; DMPU / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 47 percent / tetrahydrofuran; hexane / -78 - -70 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; 1.1: Addition / 2.1: Metallation / 2.2: Cyclization;
DOI:10.1016/S0040-4020(97)00163-4

Reference yield:

: 100-46-9
benzylamine

: 189885-42-5
2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl 4-methylphenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / tetrahydrofuran / 6 h / Heating

2.1: n-butyllithium; DMPU / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 47 percent / tetrahydrofuran; hexane / -78 - -70 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; 1.1: Addition / 2.1: Metallation / 2.2: Cyclization;
DOI:10.1016/S0040-4020(97)00163-4