Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Base Information

Chemical Name:Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester
CAS No.:384817-58-7
Molecular Formula:C₂₆H₃₇IO₅
Molecular Weight:556.481
Hs Code.:

Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Synonyms:Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Suppliers and Price of Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

There total 13 articles about Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 384817-57-6
Benzoic acid (Z)-(1R,2S)-1-[(1R,5R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclohex-2-enylmethyl]-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

: 384817-58-7
Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; at 55 ℃; for 8h;
DOI:10.1016/S0040-4039(01)01608-2

Reference yield:

: 380414-34-6
(E)-4-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-2-methyl-but-2-enoic acid

: 384817-58-7
Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 99 percent / aq. AcOH / tetrahydrofuran / 17 h / 20 °C

2: 93 percent / NaBH₄ / ethanol / 0.25 h / 20 °C

3: 86 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

4: 99 percent / LiAlH₄ / diethyl ether / 0.5 h / 20 °C

5: 87 percent / TBHP; Ti(Oi-Pr)4; (+)-DET / 4 Angstroem MS / CH₂Cl₂ / 20 h / -20 °C

6: 66 percent / Ti(Oi-Pr)4 / CHCl₃ / 8 h / 20 °C

7: imidazole / CH₂Cl₂ / 0.03 h / 20 °C

8: DIPEA / CH₂Cl₂ / 8 h / 50 °C

9: aq. TAS-F / dimethylformamide / 0.67 h / 20 °C

10: 99 percent / DMP / CH₂Cl₂ / 1 h / 20 °C

11: 61 percent / NaN(TMS)2 / 3 h / -78 °C

12: 97 percent / HF*Py / tetrahydrofuran; pyridine / 8 h / 55 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; phthalic acid dimethyl ester; sodium hexamethyldisilazane; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; tris(dimethylamino)sulfonium trimethylsilyldifluoride; 4 Angstroem MS; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 5: Sharpless' asymmetric epoxidation;
DOI:10.1016/S0040-4039(01)01608-2

Reference yield:

: 384817-69-0
(E)-4-((1R,5R,6R)-6-Formyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-2-methyl-but-2-enoic acid ethyl ester

: 384817-58-7
Benzoic acid (Z)-(1R,2S)-1-((1R,5R,6R)-6-hydroxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl)-4-iodo-2-methoxymethoxy-2-methyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / NaBH₄ / ethanol / 0.25 h / 20 °C

2: 86 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

3: 99 percent / LiAlH₄ / diethyl ether / 0.5 h / 20 °C

4: 87 percent / TBHP; Ti(Oi-Pr)4; (+)-DET / 4 Angstroem MS / CH₂Cl₂ / 20 h / -20 °C

5: 66 percent / Ti(Oi-Pr)4 / CHCl₃ / 8 h / 20 °C

6: imidazole / CH₂Cl₂ / 0.03 h / 20 °C

7: DIPEA / CH₂Cl₂ / 8 h / 50 °C

8: aq. TAS-F / dimethylformamide / 0.67 h / 20 °C

9: 99 percent / DMP / CH₂Cl₂ / 1 h / 20 °C

10: 61 percent / NaN(TMS)2 / 3 h / -78 °C

11: 97 percent / HF*Py / tetrahydrofuran; pyridine / 8 h / 55 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; phthalic acid dimethyl ester; sodium hexamethyldisilazane; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; tris(dimethylamino)sulfonium trimethylsilyldifluoride; 4 Angstroem MS; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 4: Sharpless' asymmetric epoxidation;
DOI:10.1016/S0040-4039(01)01608-2