tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Base Information

Chemical Name:tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate
CAS No.:117560-20-0
Molecular Formula:C₂₀H₂₇N₃O₆
Molecular Weight:405.451
Hs Code.:

tert-butyl (4S)-3-<(2S)-2-<N-(benzyloxycarbonyl)amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Synonyms:tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

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Technology Process of tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

There total 3 articles about tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77999-24-7
(S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester

: 117560-20-0
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 89.8 percent / K₂CO₃ / acetone / 72 h / Ambient temperature

2: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

3: 1) KOtBu / 1) THF, -50 deg C, 10 min, 2) THF, -30 to -20 deg C, 30 min

With potassium tert-butylate; hydrogen; potassium carbonate; palladium; In methanol; acetone;
DOI:10.1021/jm00122a003

Reference yield:

: 83056-78-4
tert-butyl (4S)-3-(benzyloxycarbonyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

: 117560-20-0
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

2: 1) KOtBu / 1) THF, -50 deg C, 10 min, 2) THF, -30 to -20 deg C, 30 min

With potassium tert-butylate; hydrogen; palladium; In methanol;
DOI:10.1021/jm00122a003

Reference yield:

: 83056-79-5
(4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid t-butyl ester

: 3401-36-3
(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester

: 117560-20-0
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction; 1) THF, -50 deg C, 10 min, 2) THF, -30 to -20 deg C, 30 min;
DOI:10.1021/jm00122a003