[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

Base Information

Chemical Name:[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid
CAS No.:368426-11-3
Molecular Formula:C₁₆H₂₀N₂O₆S
Molecular Weight:368.411
Hs Code.:

Synonyms:[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

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Chemical Property of [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

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Technology Process of [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

There total 1 articles about [(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 368426-11-3
[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / K₂CO₃ / tetrahydrofuran / 18 h / 20 °C

2.1: LiHMDS / tetrahydrofuran / 35 °C

2.2: 97 percent / tetrahydrofuran / 15 h / 0 - 20 °C

3.1: 100 percent / 5 M HCl / ethyl acetate / 0 - 20 °C

4.1: 83 percent / Et₃N / acetonitrile / 0 - 20 °C

5.1: H₂ / Pd/C / methanol; toluene / 2327.17 Torr

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 368426-11-3
[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

: N-(4-carbamimidoyl-benzyl)-2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: NMM; BOP / dimethylformamide / 20 °C

2: H₂ / Pd/C / methanol / 13 h / 2327.17 Torr

With 4-methyl-morpholine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 177583-27-6
tert-butyl ((1r,4r)-4-(aminomethyl)cyclohexyl)carbamate

: 368426-11-3
[(S)-3-(2,3-Dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetic acid

: 368426-43-1
[4-({2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-azepan-1-yl]-acetylamino}-methyl)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0960-894X(02)00010-0